E2F-1 (Acetyl-K117) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8820-50, ES8820-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can media

Alternate Name: Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)

Source: Rabbit

Applications: WB; ELISA

Dilution: wb dilution 1:2000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized Acetyl peptide derived from human E2F-1. at AA range: K117

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 60kD

Human Gene ID: 1869

Human SWISS Prot NO: Q01094

Subcellular Location: Nucleus

Research Use Only