Glucocorticoid Receptor Monoclonal Antibody

Catalogue Numbers: MB66792-50, MB66792-100

Sizes: 50µl, 100µl

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P04150

Host: Mouse

Reactivity: Human, Mouse

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that mediates the effects of glucocorticoids. The most abundant isoform is GR a. GR induces or represses the expression of genes in response to glucocorticoids, mediating such processes as apoptosis, cell growth and differentiation. A significant class of genes suppressed by GR is controlled by the transcription factor AP-1. GR has also been shown to be the limiting factor in the induction of gene expression by glucocorticoids. It has been revealed that GR forms a complex with HSP 90, rendering the non-ligand bound receptor transcriptionally inactive. More importantly, mutant GRs lacking the signaling domain remain constitutively active.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of Glucocorticoid Receptor protein.

Extra Notes: Western blot analysis of Glucocorticoid Receptor expression in HeLa (A), A549 (B), CCRFCEM (C), CHO (D) whole cell lysates.

Bioworld Molecular Weight: ~ 84 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: GRL; Glucocorticoid receptor; GR; Nuclear receptor subfamily 3 group C member 1

Immunogen: Recombinant fusion protein of human Glucocorticoid Receptor. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified