Tyk 2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS3976-50, BS3976-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Swiss-Prot: P29597

Host: Rabbit

Reactivity: Human

Applications: WB,

All Applications: WB: 1:1000~1:2000

Background: Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity.Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling.Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6.The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2.In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members.In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes.Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Tyk 2 polyclonal antibody detects endogenous levels of Tyk 2 protein.

Bioworld Molecular Weight: ~ 134 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Tyk 2 polyclonal antibody at 1:1000 dilution
Lane 1: SC7901 whole cell lysate (30ug)
Lane 2: SK-OVCAR3 whole cell lysate (30ug)
Lane 3: MCF-7 whole cell lysate (30ug)

Alternative Name: Non-receptor tyrosine-protein kinase TYK2

Immunogen: Synthetic peptide, corresponding to Human Tyk 2.

Conjugate: Unconjugated

Modification: Unmodified