LIPC Polyclonal Antibody

Catalogue Numbers: BS5756-50, BS5756-100

Sizes: 50µl, 100µl

Alternative Name: Hepatic triacylglycerol lipase; Short name=HL; Hepatic lipase; Lipase member C; LIPC; HTGL

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P11150

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: The Lipase family belongs to one of the most robust genetic superfamilies found in living organisms that includes esterases and thioesterases. Lipase gene products are related by tertiary structure rather than primary amino acid sequence. Balancing the composition and the transport of lipoproteins in human plasma is essential for normal body function and is mediated in part by Hepatic Lipase, also known as HL or LIPC. Rare deficiencies in Hepatic Lipase have been identified in humans which lead to pathologic levels of circulating lipoprotein particles; this condition is associated with coronary artery disease (CAD). Hepatic Lipase is regulated by thyroid hormones and has a dual function as a triglyceride hydrolase and a ligand/bridging factor for receptor-mediated lipoprotein uptake. Hepatic Lipase localizes to the endothelial surfaces of extrahepatic tissues.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: LIPC polyclonal antibody detects endogenous levels of LIPC protein.

Bioworld Molecular Weight: ~ 56 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of LIPC polyclonal antibody at 1:500 dilution
Lane 1: HEK293T cell lysate
Lane 2: NIH-3T3 cell lysate
Lane 3: H9C2 cell lysate

Immunogen: Synthetic peptide, corresponding to the 349-394 of Human LIPC.

Conjugate: Unconjugated

Modification: Unmodified